منابع مشابه
NO signalling in synaptic transmission
Background The NO/cGMP signaling cascade has been proposed to play a role in long-term potentiation (LTP) and the modulation of synaptic transmission. Nitric oxide is formed enzymatically by NO synthases (NOS); two NOS, the endothelial and neuronal isoform (eNOS, nNOS) produce NO as a signalling molecule. Functionally, NO has been reported to act as a retrograde messenger that is generated post...
متن کاملNO/cGMP-dependent modulation of synaptic transmission.
Nitric oxide (NO) is a multifunctional messenger in the CNS that can signal both in antero- and retrograde directions across synapses. Many effects of NO are mediated through its canonical receptor, the soluble guanylyl cyclase, and the second messenger cyclic guanosine-3',5'-monophosphate (cGMP). An increase of cGMP can also arise independently of NO via activation of membrane-bound particulat...
متن کاملThe effect of ketamine on synaptic transmission and synaptic plasticity in CA1 area of rat hippocampal slices
The effect of ketamine (1-100 µM), which has NMDA receptor antagonist properties, on synaptic transmission and long-term potentiation (LTP) in CAl area of rat hippocampus was examined in vitro. Field potentials were recorded in pyramidal cell layer following Schaffer collateral stimulation. Primed-burst stimulation (PEs) was used for induction of LTP. The amplitude of population spiks (PS) was ...
متن کاملMuscarinic modulation of synaptic transmission via endocannabinoid signalling in the rat midbrain periaqueductal gray.
The midbrain periaqueductal gray (PAG) is involved in organizing behavioral responses to threat, stress, and pain. These PAG functions are modulated by cholinergic agents. In the present study, we examined the cholinergic modulation of synaptic transmission in the PAG using whole-cell voltage-clamp recordings from rat midbrain slices. We found that the cholinergic agonist carbachol reduced the ...
متن کاملMuscarinic modulation of synaptic transmission via endocannabinoid signalling in the rat midbrain periaqueductal grey
The midbrain periaqueductal grey (PAG) is involved in organizing behavioural responses to threat, stress and pain. These PAG functions are modulated by cholinergic agents. In the present study, we examined the cholinergic modulation of synaptic transmission in the PAG using whole-cell voltage-clamp recordings from rat midbrain slices. We found that the cholinergic agonist carbachol reduced the ...
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ژورنال
عنوان ژورنال: BMC Pharmacology
سال: 2011
ISSN: 1471-2210
DOI: 10.1186/1471-2210-11-s1-o21